Inhibition of angiogenesis and tumour growth by VEGF121–toxin conjugate: differential effect on proliferating endothelial cells
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چکیده
منابع مشابه
Inhibition of growth factor-induced Ras signaling in vascular endothelial cells and angiogenesis by 3,3'-diindolylmethane.
3,3'-Diindolylmethane (DIM), an indole derivative produced on consumption of broccoli and other cruciferous vegetables, has been shown to have multiple anticancer effects in both in vivo and in vitro models. The present study was carried out to clarify the mechanism of DIM's antiangiogenic activity. We found that DIM can inhibit vascular endothelial growth factor (VEGF)-induced cell proliferati...
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چکیده ندارد.
15 صفحه اولcloning and expression of vascular endothelial growth factor receptor-1 in escherichia coli and analysis of its growth inhibition effect on human umbilical vein endothelial cells
objective: angiogenesis a process that results in neo-vascularization is an essential stage in growth of solid tumors and the formation of metastases. vascular endothelial growth factor (vegf) and its receptors, vegfr1 (flt-1) and vegfr2 (kdr/flk-1), are the major regulators for tumor angiogenesis. recent studies showed that second domain of vegfr-1is a key factor for vegf/vegfr-1 interaction. ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2000
ISSN: 0007-0920,1532-1827
DOI: 10.1054/bjoc.2000.1439